Tablet Presentation

Each film coated tablets contains:
1. Cefixime Trihydrate IP      100 mg
Ofloxacin IP                                100 mg

2. Cefixime Trihydrate IP      200 mg
Ofloxacin IP                                200 mg

Cefixime Trihydrate is a cephalosporin antibiotic used to treat infections caused by bacteria such as pneumonia; bronchitis; gonorrhea; and ear, lung, throat, and urinary tract infections.

Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone.


Preferred Choice For:
  • Typhoid Fever
  • Urinary Tract Infection
  • Respiratory Tract Infection
  • Nosocomial Infections
  • Soft Tissue Infections
  • Surgical Prophylaxi
  • Intra-abdominal Infections
  • Skin and skin structure infections and bone and joint infections.
  • Acute bronchttis and acute exacerbations of chronic bronchitis, caused by streptococcus pneumoniae and haemophilus influenzae (beta-lactamase posttive and negative strains).


Cefixime Trihydrate

Cefixime is an orally active third generation bactericidal cephalosporin ( beta lactam antibiotic) with broad spectrum of coverage . Cefixime has been shown to be active against most strains of the Gram-positive organisms. As with other cephalosporins, bactericidal action of cefixime results from inhibition of bacterial cell- wall synthesis. The peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the synthesis of the peptidoglycan is facilitated by transpeptidases known as penicillin binding proteins (PBPs). PBPs bind to the D-Ala-D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam antibiotics mimic this site and competitively inhibit PBP crosslinking of peptidoglycan. Cefixime is highly stable in the presence of betalactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime.


Ofloxacin belongs to a class of antibiotics called fluoroquinolones and used in adults to treat certain infections caused by certain germs called bacteria. Ofloxacin is an antibiotic that stops bacteria multiplication by inhibiting the reproduction and repair of their genetic material (DNA). Ofloxacin inhibits the enzyme Bacterial DNA gyrase,which nicks double standard DNA introduces negative super coils and then repeals the nicked ends. The DNA gyrase consists of; two A subunits and two B subunits, A subunit consist of nicking of DNA while B subunit introduces -ve super coils and then A subunit repeals the stands. Ofloxacin binds to A subunit with high affinity and interfere with it's strand cutting & repealing function. In Gram positive bacteria the major target of Ofloxacin action is a similar enzymes Topoisomerase. In place of DNA gyrase or Topoisomerase-4 enzyme the mammalian cells passess an Topoisomerase 2 , which has very low affinity for Ofloxacin, hence less toxicity to the host Cells. Ofloxacin is used to treat pneumonia and bronchitis caused by Haemophilus influenzae and Streptococcus pneumoniae. It is also used in treating skin infections caused by staphylococcus aureus, and streptococcus pyogenes bacteria. Ofloxacin is used to treat sexually transmitted diseases i.e, gonorrhea and chlamydia, but is not effective against syphilis. Ofloxacin is often used to treat urinary infections and prostate infections caused by E. Coli.

Side Effects

Most of adverse reactions observed in clinical trials were of a mild and transient nature. The most commonly seen adverse reactions in clinical trials of the tablet formulation were gastrointestinal and also adverse reaction have been reported for cephalosporin sensitive person and also in some cases somnolence, nasopharyngitis, fatigue, dry mouth and pharyngitis, and most were mild to moderate in intensity.


This tablet is contraindicated in patients with known allergies to the cephalosporin or penicillin or fluoroquinolone antibiotics.

Drug Interaction

Elevated carbamazepine levels have been reported when tablet is administered concomitantly with carbazepine salt and with warfarin and anticoagulants drugs, the prothrombin time is incecreased when this tablet is administered concomitantly. Ofloxacin form chelates with alkaline earth and transition metal cations when administration of with antacids is containing calcium, magnesium, or aluminum, with sucralfate, with divalent or trivalent cations such as iron, or with multivitamins containing zinc. Elevated serum levels of cyclosporine have been reported with concomitant use of cyclosporine with some other quinolones.

Rationale of Combination

  • Unique Dual Mode Of Action
  • Ofloxacin-Prevents nucleic acid synthesis
  • Cefixime-Inhibits cell wall synthesis


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